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From Wikipedia:
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Itachi Uchiha (うちは イタチ ,Uchiha Itachi) is a fictional character in the Naruto manga and anime series created by Masashi Kishimoto. In the series, Itachi is the older brother of Sasuke Uchiha responsible for killing all the members of their clan. However, during Part II of the series, it is revealed that Itachi was ordered by the former leaders of Konohagakure to kill the Uchiha who were attempting to start a war. Despite his reservations, Itachi fulfilled his mission and defected from Konohagakure to become part of the criminal organization Akatsuki. Itachi has not been featured in the films and original video animations from Naruto, but he is a playable character in most video games of the series. |
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Pain, in the sense of physical pain, is a typical sensory experience that may be described as the unpleasant awareness of a noxious stimulus or bodily harm. Individuals experience pain by various daily hurts and aches, and occasionally through more serious injuries or illnesses. For scientific and clinical purposes, pain is defined by the International Association for the Study of Pain (IASP) as "an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage".
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Pain vs Tsunade, 
