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Keflex vs Cipro

Created: June 10, 2009, Updated: June 09, 2014, Owner: claim ownershipPut your name here Comments (0)
 

Keflex

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Cipro

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Cefalexin (INN, BAN) or cephalexin (USAN, AAN) /ˌsɛfəˈlɛksɨn/ is an antibiotic useful for the treatment of a number of bacterial infections. It is taken by mouth and is active against gram positive bacteria and some gram negative bacteria. It is in the class of first generation cephalosporins and has similar activity to other agents within this group including the intravenous agent cefazolin. –Editor's choicemore
Ciprofloxacin (INN) is an antibiotic useful for the treatment of a number of bacterial infections. It is a second-generation fluoroquinolone. Its spectrum of activity includes most strains of bacterial pathogens responsible for respiratory, urinary tract, gastrointestinal, and abdominal infections, including Gram-negative (Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Legionella pneumophila, Moraxella catarrhalis, Proteus mirabilis, and Pseudomonas aeruginosa), and Gram-positive (methicillin-sensitive but not methicillin-resistant Staphylococcus aureus, Streptococcus pneumoniae, Staphylococcus epidermidis, Enterococcus faecalis, and Streptococcus pyogenes) bacterial pathogens. Ciprofloxacin and other fluoroquinolones are valued for this broad spectrum of activity, excellent tissue penetration, and for their availability in both oral and intravenous formulations. –Editor's choicemore
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Trade namesKeflex, Cepol, Ceporexine, CeporexCiloxan, Cipro, Neofloxin
AHFS/Drugs.commonographmonograph
MedlinePlusa682733a688016
Licence dataUS FDA:linkUS FDA:link
Pregnancy cat.A (AU) B (US)B3 (AU) C (US)
Legal statusPrescription Only (S4) (AU) POM (UK) ℞-only (US)Prescription Only (S4) (AU) POM (UK) ℞-only (US)
RoutesOralOral, intravenous, topical (ear drops, eye drops)
BioavailabilityWell absorbed69%
Metabolism80% excreted unchanged in urine within 6 hours of administrationHepatic, including CYP1A2
Half-lifeFor an adult with normal renal function, the serum half-life is 0.5-1.2 hours4 hours
ExcretionRenalRenal
CAS number15686-71-285721-33-1
ATC codeJ01DB01 QJ51DB01J01MA02 S01AE03 S02AA15 S03AA07
PubChemCID 2666CID 2764
DrugBankDB00567DB00537
ChemSpider255412662
UNII5SFF1W66775E8K9I0O4U
KEGGD00263D00186
ChEBICHEBI:3534CHEBI:100241
ChEMBLCHEMBL1727CHEMBL8
FormulaC16H17N3O4SC17H18FN3O3
Mol. mass347.39 g/mol331.346 g/mol
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