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LAMICTAL vs Neurontin

Created: August 06, 2009, Updated: June 07, 2014, Owner: claim ownershipPut your name here Comments (0)
 

LAMICTAL

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Neurontin

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Lamotrigine /ləˈmoʊtrɨˌdʒiːn/, marketed in most of the world as Lamictal /ləˈmɪktəl/ by GlaxoSmithKline, is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. It is also used off-label as an adjunct in treating clinical depression. For epilepsy, it is used to treat focal seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Like many other anticonvulsant medications, lamotrigine also seems to act as an effective mood stabilizer, and has been the first US Food and Drug Administration (FDA)-approved drug for this purpose since lithium, a drug approved almost 30 years earlier. It is approved for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants (due to lamotrigine being a phenyltriazine), lamotrigine has many possible side-effects. Lamotrigine is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs, but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and carbamazepine and is effective in the treatment of the depressed phase of bipolar disorder, where as other sodium channel blocking antiepileptic drugs are not. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasises its unique properties. Lamotrigine is inactivated by hepatic glucuronidation. –Editor's choicemore
Gabapentin (Neurontin) is a pharmaceutical drug, specifically a GABA analog. It was originally developed to treat epilepsy, and currently is also used to relieve neuropathic pain. It is recommended as a first line agent for the treatment of neuropathic pain arising from diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain. –Editor's choicemore
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Trade namesLamictalFanatrex, Gabarone, Gralise, Neurontin, Nupentin, Neogab
AHFS/Drugs.commonographmonograph
MedlinePlusa695007a694007
Licence dataUS FDA:linkUS Daily Med:link
Pregnancy cat.D (AU) C (US)B1 (AU) C (US)
Legal statusPrescription Only (S4) (AU) ℞-only (CA) POM (UK) ℞-only (US)Prescription Only (S4) (AU) ℞-only (CA) POM (UK) ℞-only (US)
RoutesOralOral
Bioavailability98%27-60% (inversely proportional to dose; a high fat meal also increases bioavailability)
Protein binding55%Less than 3%
MetabolismHepatic (mostly UGT1A4-mediated)Not significantly metabolised
Half-life29 hours5 to 7 hours
ExcretionUrine (65%), faeces (2%)Renal
CAS number84057-84-160142-96-3
ATC codeN03AX09N03AX12
PubChemCID 3878CID 3446
DrugBankDB00555DB00996
ChemSpider37413328
UNIIU3H27498KS6CW7F3G59X
KEGGD00354D00332
ChEBICHEBI:6367CHEBI:42797
ChEMBLCHEMBL741CHEMBL940
FormulaC9H7Cl2N5C9H17NO2
Mol. mass256.091 g/mol171.237 g/mol
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