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Simvastatin vs Crestor

Created: November 16, 2009, Updated: June 01, 2014, Owner: claim ownershipPut your name here Comments (0)
 

Simvastatin

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Crestor

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Simvastatin (INN) /ˈsɪmvəstætɨn/ is a hypolipidemic drug used with exercise, diet, and weight-loss to control elevated cholesterol, or hypercholesterolemia. It is a member of the statin class of pharmaceuticals. Simvastatin is a synthetic derivative of a fermentation product of Aspergillus terreus. The drug is marketed generically following the patent expiration, and under the trade name Zocor. –Editor's choicemore
Rosuvastatin (marketed by AstraZeneca as Crestor, In India marketed by Zydus CND as Zyrova) is a member of the drug class of statins, used in combination with exercise, diet, and weight-loss to treat high cholesterol and related conditions, and to prevent cardiovascular disease. It was developed by Shionogi. Crestor is the fifth-highest selling drug in the United States, accounting for approx. $2.6 billion in sales in 2013. –Editor's choicemore
Trade namesZocorCrestor, R2
AHFS/Drugs.commonographmonograph
MedlinePlusa692030a603033
Pregnancy cat.D (AU) X (US)D (AU) X (US)
Legal statusPrescription Only (S4) (AU) P (UK) ℞-only (US)Prescription Only (S4) (AU) POM (UK) ℞-only (US)
RoutesOraloral
Bioavailability5%20%
Protein binding95%88%
MetabolismHepatic (CYP3A4)Liver (CYP2C9 and CYP2C19-mediated; only minimally (~10%) metabolised)
Half-life2 hours for simvastatin and 1.9 hours for simvastatin acid19 hours
ExcretionRenal 13%, faecal 60%Faeces
CAS number79902-63-9287714-41-4
ATC codeC10AA01C10AA07
PubChemCID 54454CID 446157
DrugBankDB00641DB01098
ChemSpider49179393589
UNIIAGG2FN16EV413KH5ZJ73
KEGGD00434D01915
ChEBICHEBI:9150CHEBI:38545
ChEMBLCHEMBL1064CHEMBL1496
FormulaC25H38O5C22H28FN3O6S
Mol. mass418.566 g/mol481.539
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